Dosage, Side Effects & Pregnancy Safety

What are the uncomfortable side effects of Xiaflex?

WARNING

Corporal Rupture (Penile Fracture) or Other Serious Penile Injury within the Treatment of Peyronie’s Disease

Corporal rupture (penile fracture) was reported as an antagonistic response in 5 of 1044 (0.5%) Xiaflex-treated sufferers in medical research. In different Xiaflex-treated sufferers (9 of 1044; 0.9%), a mixture of penile ecchymoses or hematoma, sudden penile detumescence, and/or a penile “popping” sound or sensation was reported, and in these instances, a analysis of corporal rupture can’t be excluded. Severe penile hematoma was additionally reported as an antagonistic response in 39 of 1044 (3.7%) Xiaflex-treated sufferers.

Signs or signs which will mirror severe penile damage needs to be promptly evaluated to evaluate for corporal rupture or extreme penile hematoma which can require surgical intervention.

Because of the dangers of corporal rupture or different severe penile damage, Xiaflex is obtainable for the remedy of Peyronie’s illness solely by means of a restricted program beneath a Risk Evaluation and Mitigation Strategy (REMS) known as the Xiaflex REMS Program.

Xiaflex could trigger severe uncomfortable side effects, together with:

elevated likelihood of bleeding. Bleeding or bruising on the injection web site can occur in individuals who obtain Xiaflex. Talk to your healthcare supplier in case you have an issue together with your blood clotting. Xiaflex might not be best for you.

What is a very powerful info I ought to learn about Xiaflex for the remedy of Dupuytren’s contracture?

Xiaflex may cause severe uncomfortable side effects, together with:

  • Tendon rupture or ligament harm. Receiving an injection of Xiaflex could trigger harm to a tendon or ligament in your hand and trigger it to interrupt or weaken. This may require surgical procedure to repair the broken tendon or ligament. Call your healthcare supplier instantly in case you have bother bending your injected finger (in the direction of the wrist) after the swelling goes down or you’ve issues utilizing your handled hand after your follow-up go to.
  • Nerve damage or different severe damage of the hand. Call your healthcare supplier instantly if you happen to get numbness, tingling, elevated ache, or tears within the pores and skin (laceration) in your handled finger or hand after your injection or after your follow-up go to.
  • Hypersensitivity reactions, together with anaphylaxis. Severe allergic reactions can occur in individuals who obtain Xiaflex, as a result of it incorporates overseas proteins.

Call your healthcare supplier instantly in case you have any of those signs of an allergic response after an injection of Xiaflex:

The most typical uncomfortable side effects with Xiaflex for the remedy of Dupuytren’s contracture embrace:

  • swelling of the injection web site or the hand
  • bruising or bleeding on the injection web site
  • ache or tenderness of the injection web site or the hand
  • swelling of the lymph nodes (glands) within the elbow or armpit (axilla)
  • itching
  • breaks within the pores and skin
  • redness or heat of the pores and skin
  • ache within the armpit

What is a very powerful info I ought to learn about Xiaflex for the remedy of Peyronie’s illness?

Xiaflex may cause severe uncomfortable side effects, together with:

  • Penile fracture (corporal rupture) or different severe damage to the penis. Receiving an injection of Xiaflex could trigger harm to the tubes in your penis known as the corpora. After remedy with Xiaflex, certainly one of these tubes could break throughout an erection. This known as a corporal rupture or penile fracture. This may require surgical procedure to repair the broken space. Damage to your penis won’t get higher after a corporal rupture.
    • After remedy with Xiaflex, blood vessels in your penis may break, inflicting blood to gather beneath the pores and skin (hematoma). This may require a process to empty the blood from beneath the pores and skin.
      • Symptoms of corporal rupture or different severe damage to your penis could embrace:
        • a popping sound or sensation in an erect penis
        • sudden lack of the power to keep up an erection
        • ache in your penis
        • purple bruising and swelling of your penis
        • issue urinating or blood within the urine

Call your healthcare supplier instantly in case you have any of the signs of corporal rupture or severe damage to the penis listed above.

Do not have intercourse or some other sexual exercise between the primary and second injections of a remedy cycle.

Do not have intercourse or have some other sexual exercise for not less than four weeks after the second injection of a remedy cycle with Xiaflex and after any ache and swelling has gone away.

Xiaflex for the remedy of Peyronie’s illness is barely obtainable by means of a restricted program known as the Xiaflex Risk Evaluation and Mitigation Strategy (REMS) Program. For extra details about the Xiaflex REMS Program go to www.XiaflexREMS.com or name 1-877-942-3539.

  • Hypersensitivity reactions, together with anaphylaxis. Severe allergic reactions can occur in individuals who obtain Xiaflex, as a result of it incorporates overseas proteins.

Call your healthcare supplier instantly in case you have any of those signs of an allergic response after an injection of Xiaflex:

The most typical uncomfortable side effects with Xiaflex for the remedy of Peyronie’s illness embrace:

  • a small assortment of blood beneath the pores and skin on the injection web site (hematoma)
  • swelling on the injection web site or alongside your penis
  • ache or tenderness on the injection web site, alongside your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection issues (erectile dysfunction)
  • adjustments within the coloration of the pores and skin of your penis
  • blisters on the injection web site
  • ache with intercourse
  • a lump on the injection web site (nodule)

Tell your healthcare supplier in case you have any aspect impact that bothers you or doesn’t go away.

These usually are not the entire attainable uncomfortable side effects with Xiaflex. For extra info, ask your healthcare supplier or pharmacist.

Call your physician for medical recommendation about uncomfortable side effects. You could report uncomfortable side effects to FDA at 1-800-FDA-1088.

Lasix (furosemide) Side Effects, Warnings, and Drug Interactions

What medicine work together with Lasix (furosemide)?

Lasix could enhance the ototoxic potential of
aminoglycoside antibiotics, particularly within the presence of impaired renal
perform. Except in life-threatening conditions, keep away from this mixture.

Lasix shouldn’t be used concomitantly with ethacrynic
acid due to the opportunity of ototoxicity. Patients receiving excessive doses
of salicylates concomitantly with Lasix, as in rheumatic illness, could
expertise salicylate toxicity at decrease doses due to aggressive renal
excretory websites.

There is a threat of ototoxic results if cisplatin and
Lasix are given concomitantly. In addition, nephrotoxicity of nephrotoxic medicine
akin to cisplatin could also be enhanced if Lasix will not be given in decrease doses and with
constructive fluid steadiness when used to realize compelled diuresis throughout cisplatin
remedy.

Lasix tends to antagonize the skeletal muscle
enjoyable impact of tubocurarine and should potentiate the motion of
succinylcholine.

Lithium usually shouldn’t be given with diuretics
as a result of they scale back lithium’s renal clearance and add a excessive threat of lithium
toxicity.

Lasix mixed with angiotensin changing enzyme
inhibitors or angiotensin II receptor blockers could result in extreme hypotension
and deterioration in renal perform, together with renal failure. An interruption
or discount within the dosage of Lasix, angiotensin changing enzyme inhibitors,
or angiotensin receptor blockers could also be mandatory.

Potentiation happens with ganglionic or peripheral
adrenergic blocking medicine.

Lasix could lower arterial responsiveness to
norepinephrine. However, norepinephrine should be used successfully.

Simultaneous administration of sucralfate and Lasix
tablets could scale back the natriuretic and antihypertensive results of Lasix.
Patients receiving each medicine must be noticed carefully to find out if the
desired diuretic and/or antihypertensive impact of Lasix is achieved. The
consumption of Lasix and sucralfate must be separated by at the very least two hours.

In remoted circumstances, intravenous administration of Lasix
inside 24 hours of taking chloral hydrate could result in flushing, sweating
assaults, restlessness, nausea, enhance in blood stress, and tachycardia. Use
of Lasix concomitantly with chloral hydrate is due to this fact not beneficial.

Phenytoin interferes straight with renal motion of Lasix.
There is proof that remedy with phenytoin results in lower intestinal
absorption of Lasix, and consequently to decrease peak serum furosemide
concentrations.

Methotrexate and different medicine that, like Lasix, endure
vital renal tubular secretion could scale back the impact of Lasix. Conversely,
Lasix could lower renal elimination of different medicine that endure tubular
secretion. High-dose remedy of each Lasix and these different medicine could outcome
in elevated serum ranges of those medicine and should potentiate their toxicity as
effectively because the toxicity of Lasix.

Lasix can enhance the chance of cephalosporin-induced
nephrotoxicity even within the setting of minor or transient renal impairment.

Concomitant use of cyclosporine and Lasix is related
with elevated threat of gouty arthritis secondary to Lasix-induced hyperurecemia
and cyclosporine impairment of renal urate excretion.

High doses ( > 80 mg) of furosemide could inhibit the
binding of thyroid hormones to provider proteins and lead to transient
enhance in free thyroid hormones, adopted by an general lower in complete thyroid
hormone ranges.

One examine in six topics demonstrated that the
mixture of furosemide and acetylsalicylic acid briefly decreased
creatinine clearance in sufferers with continual renal insufficiency. There are
case stories of sufferers who developed elevated BUN, serum creatinine and
serum potassium ranges, and weight achieve when furosemide was utilized in conjunction
with NSAIDs.

Literature stories point out that coadministration of
indomethacin could scale back the natriuretic and antihypertensive results of Lasix
(furosemide) in some sufferers by inhibiting prostaglandin synthesis.
Indomethacin may additionally have an effect on plasma renin ranges, aldosterone excretion, and
renin profile analysis. Patients receiving each indomethacin and Lasix ought to
be noticed carefully to find out if the specified diuretic and/or
antihypertensive impact of Lasix is achieved.

Drug Facts, Side Effects, Dosage

What is liothyronine sodium, and the way does it work (mechanism of motion)?

Liothyronine sodium is an artificial (man-made) model of one of many two hormones made by the thyroid gland, triiodothyronine. It is used for treating people who’re hypothyroid (don’t produce sufficient thyroid hormones). Thyroid hormones enhance the metabolism (exercise) of all cells within the physique. In the fetus, new child toddler and youngster, thyroid hormones promote progress and growth of tissues. In adults, thyroid hormones assist to take care of the operate of the mind, the usage of meals by the physique, and physique temperature. The FDA authorized liothyronine in May 1956.

What model names can be found for liothyronine sodium?

Cytomel, Triostat

Is liothyronine sodium out there as a generic drug?

GENERIC AVAILABLE: Yes

Do I want a prescription for liothyronine sodium?

Yes

What are the makes use of for liothyronine sodium?

Liothyronine sodium (Cytomel, Triostat) is a drug prescribed to deal with hypothyroidism, and to deal with and stop varied sorts of euthyroid goiters.

What are the uncomfortable side effects of liothyronine sodium?

Liothyronine remedy usually is well-tolerated. If signs happen, they often happen as a result of there are poisonous (too excessive) ranges of thyroid hormone (hyperthyroidism).

Symptoms of hyperthyroidism embrace:

  • chest ache,
  • elevated coronary heart price,
  • extreme sweating,
  • warmth intolerance,
  • nervousness,
  • headache,
  • tremor,
  • insomnia,
  • diarrhea,
  • vomiting,
  • weight reduction,
  • fever, and,
  • hardly ever, cardiac arrest.

Women additionally might expertise irregular menstrual cycles.

Since thyroid hormone impacts coronary heart price and metabolism, the impression of therapy of thyroid hormone on the management of ailments akin to atrial fibrillation, diabetes and excessive levels of cholesterol all the time must be thought-about.



QUESTION


Where is the thyroid gland positioned?
See Answer

What is the dosage for liothyronine sodium?

The standard beginning dose of liothyronine for treating hypothyroidism is 5 to 25 mcg per day. The dose then is adjusted primarily based on the affected person’s response and the blood ranges of thyroid hormone. Optimal liothyronine doses are totally different for every affected person and differ relying on the affected person’s age, weight, signs, blood ranges of thyroid hormone and underlying circumstances akin to coronary heart illness. Individuals who’re hypothyroid would require thyroid hormone for all times.

Which medicine or dietary supplements work together with liothyronine sodium?

Thyroid hormone impacts the physique’s dealing with of many medicine. Generally, hypothyroidism (decreased focus of thyroid hormone) reduces the results of the physique on medicine (metabolism of medication) whereas hyperthyroidism (elevated focus of thyroid hormone) will increase the results. Therefore, people who’re hypothyroid will eradicate medicine extra slowly, and people with hyperthyroidism will eradicate medicine quicker in contrast with people with regular ranges of thyroid hormone.

This precept additionally applies to the metabolism of medication that should be metabolized (modified) by the physique into their lively varieties as a way to have an impact. Therefore, liothyronine and different thyroid hormones might change the motion of many medicine. The elimination of theophylline (Theo-Dur) and comparable medicine will increase because the dose of thyroid hormone will increase. Individuals who’re hypothyroid have slower theophylline elimination. Therefore, when the focus of thyroid hormone is returned to regular with liothyronine, the elimination of theophylline is elevated. This reduces the focus of theophylline within the physique and may scale back the effectiveness of theophylline. Patients who’re handled for thyroid circumstances and who’re taking theophylline ought to have their blood focus of theophylline monitored, and doses of theophylline must be adjusted as mandatory.

Cholestyramine (Questran) binds liothyronine and different thyroid in hormones within the gut, decreasing the absorption and ranges of liothyronine. Thyroid hormones shouldn’t be administered for four to five hours after administering cholestyramine.

The administration of liothyronine will increase the motion of the blood thinning drug, warfarin (Coumadin). Warfarin acts by decreasing the focus of things within the physique which are mandatory for blood to clot. The focus of those clotting components within the physique is set by the physique’s price of metabolism. In principle, by growing the physique’s metabolism (elimination) of those clotting components, thyroid hormones scale back the physique’s potential to clot and due to this fact improve the results of warfarin. Since this could result in extreme bleeding, the dose of warfarin might should be decreased.

Is liothyronine sodium secure to take if I’m pregnant or breastfeeding?

Thyroid hormones don’t simply cross the placenta and, due to this fact, are secure for pregnant ladies to take.

Very small quantities of thyroid hormone could also be excreted in breast milk. This will not be a major problem for breastfed infants.

What else ought to I find out about liothyronine sodium?

What preparations of liothyronine sodium can be found?

Tablets: 5, 25, and 50 mcg. Injection: 10 mcg/ml

How ought to I maintain liothyronine sodium saved?

Tablets must be saved at room temperature 20 C – 25 C (68 F – 77 F) and the injectable preparation between 2 C – eight C (36 F – 46 F )




SLIDESHOW


Hyperthyroidism Symptoms and Treatment
See Slideshow

Medically Reviewed on 7/31/2019

References


FDA Prescribing Information

Hyperkalemia Drug Dosage & Side Effects

What is Veltassa (patiromer), and what’s it used for?

Veltassa is indicated for the remedy of hyperkalemia, or excessive ranges of potassium. High ranges of potassium normally are attributable to kidney or adrenal gland malfunctions and should trigger

Veltassa works within the colon by binding with potassium out of your meals and stopping your physique from absorbing it.

  • Veltassa shouldn’t be used as an emergency remedy for life-threatening hyperkalemia due to its delayed onset of motion
  • Veltassa is contraindicated in sufferers with a historical past of a hypersensitivity response to Veltassa or any of its elements
  • Because Veltassa just isn’t absorbed into the bloodstream, docs take into account it low-risk for pregnant ladies and nursing moms.

What are the uncomfortable side effects of Veltassa (patiromer)?

Worsening of Gastrointestinal Motility

Avoid use of Veltassa in sufferers with extreme constipation, bowel obstruction or impaction, together with irregular post-operative bowel motility problems, as a result of Veltassa could also be ineffective and should worsen gastrointestinal situations.

Patients with a historical past of bowel obstruction or main gastrointestinal surgical procedure, extreme gastrointestinal problems, or swallowing problems weren’t included within the scientific research.

Hypomagnesemia

Veltassa binds to magnesium within the colon, which might result in hypomagnesemia. In scientific research, hypomagnesemia was reported as an opposed response in 5.3% of sufferers handled with Veltassa. Monitor serum magnesium.

Consider magnesium supplementation in sufferers who develop low serum magnesium ranges on Veltassa.

During the scientific research, probably the most generally reported opposed reactions resulting in discontinuation of Veltassa had been gastrointestinal opposed reactions (2.7%), together with

Mild to average hypersensitivity reactions had been reported in 0.3% of sufferers handled with Veltassa in scientific trials. Reactions have included edema of the lips.

What is the dosage for Veltassa (patiromer)?

Administer Veltassa at the least Three hours earlier than or Three hours after different oral drugs

Do not warmth Veltassa (e.g., microwave) or add to heated meals or liquids. Do not take Veltassa in its dry type.

  • Measure 1/Three cup of water.
  • Pour half of the water right into a glass, then add Veltassa and stir.
  • Add the remaining half of the water and stir completely.
  • The powder won’t dissolve and the combination will look cloudy.
  • Add extra water to the combination as wanted for desired consistency.
  • Drink the combination instantly.
  • If powder stays within the glass after consuming, add extra water, stir and drink instantly. Repeat as wanted to make sure your complete dose is run.

The really useful beginning dose of Veltassa is 8.four grams patiromer as soon as every day. Monitor serum potassium and alter the dose of Veltassa based mostly on the serum potassium stage and the specified goal vary.

The dose could also be elevated or decreased, as obligatory, to achieve the specified serum potassium focus, as much as a most dose of 25.2 grams as soon as every day. The dose will be up-titrated based mostly on serum potassium stage at 1-week or longer intervals, in increments of 8.four grams.



QUESTION


The solely objective of the kidneys is to filter blood.
See Answer

What medication work together with Veltassa (patiromer)?

In scientific research, Veltassa decreased systemic publicity of some coadministered oral drugs. Binding of Veltassa to different oral drugs might trigger decreased gastrointestinal absorption and lack of efficacy when taken near the time Veltassa is run.

Administer different oral drugs at the least Three hours earlier than or Three hours after Veltassa.

Is Veltassa (patiromer) protected to take whereas pregnant or breastfeeding?

Veltassa just isn’t absorbed systemically following oral administration and maternal use just isn’t anticipated to end in fetal threat. Veltassa just isn’t absorbed systemically by the mom, so breastfeeding just isn’t anticipated to end in threat to the toddler.

Medically Reviewed on 3/18/2020

References


Most article content material courtesy of the U.S. Food and Drug Administration

methimazole (Tapazole) Side Effects, Dosage & Pregnancy Safety

What is methimazole, and the way does it work (mechanism of motion)?

Methimazole is used to deal with an overactive thyroid gland (hyperthyroidism). Grave’s illness is the most typical reason for hyperthyroidism. Grave’s illness is an autoimmune illness ensuing from antibodies that connect to receptors on thyroid hormone-producing cells within the thyroid gland and set off overproduction of thyroid hormone. An enzyme (peroxidase) produces thyroid hormones, i.e., thyroxine (T4) and triiodothyronine (T3), by combining iodine with a protein known as thyroglobulin. Methimazole prevents iodine and peroxidase from their regular interactions with thyroglobulin to kind T4 and T3. This motion decreases thyroid hormone manufacturing. Methimazole additionally interferes with the conversion of T4 to T3. Since T3 is stronger than T4, this additionally reduces the exercise of thyroid hormones. The FDA accepted methimazole in March 1999.

What model names can be found for methimazole?

Tapazole, Northyx (discontinued)

Is methimazole obtainable as a generic drug?

Yes

Do I want a prescription for methimazole?

Yes

What is methimazole used for?

Methimazole is used for treating hyperthyroidism. It is also used for reducing signs of hyperthyroidism in preparation for surgical elimination of the thyroid gland or earlier than inactivating the thyroid gland with radioactive iodine. Long-term use of methimazole could result in a remission of the hyperthyroidism.

What are the negative effects of methimazole?

Methimazole is mostly well-tolerated with negative effects occurring in three out of each 100 sufferers. The most typical negative effects are associated to the pores and skin and embrace:

Other widespread negative effects are:

Less widespread however extra critical negative effects embrace a lower in white blood cells (agranulocytosis) and blood platelets (thrombocytopenia). Symptoms and indicators of agranulocytosis embrace infections of the throat, the gastrointestinal tract, and pores and skin with an total feeling of sickness and fever. Since platelets are vital for the clotting of blood, thrombocytopenia could result in issues with extreme bleeding. Hepatitis and loss of life of liver cells (hepatic necrosis) have hardly ever been related to methimazole.

What is the dosage for methimazole?

The preliminary grownup dose of methimazole is:

  • 15 mg/day for delicate hyperthyroidism
  • 30-40 mg/day for reasonably extreme hyperthyroidism
  • 60 mg/day for extreme hyperthyroidism

The every day dose is split into three doses administered each eight hours.

The upkeep dose is 5-15 mg/day.

The standard preliminary youngsters’s dose is 0.four mg/kg given in three divided doses administered eight hours aside, and the upkeep dose is half the preliminary dose.



QUESTION


Where is the thyroid gland situated?
See Answer

Which medicine or dietary supplements work together with methimazole?

Warfarin (Coumadin) works by lowering the exercise of vitamin Ok and subsequently the formation of vitamin Ok dependent clotting components. Methimazole could enhance the exercise of warfarin by additional lowering the exercise of vitamin Ok within the physique.

Hyperthyroidism will increase elimination of beta blockers. Correcting hyperthyroidism will trigger much less elimination of beta blockers. Therefore, the dose of beta blockers could require discount when hyperthyroidism is corrected. An analogous response might also happen with digoxin (Lanoxin) and theophylline (Respbid, Slo-Bid, Theo-24, Theolair).

Is methimazole secure to take if I’m pregnant or breastfeeding?

Methimazole is excreted in breast milk and will probably trigger hurt to the toddler.

What else ought to I find out about methimazole?

What preparations of methimazole can be found?

Tablet: 5, 10 mg

How ought to I preserve methimazole saved?

Methimazole ought to be saved at room temperature, 15 C and 30 C (59 F and 86 F).

Medically Reviewed on 10/15/2019

References

Medically reviewed by Eni Williams; PharmD., Ph.D.
REFERENCE:

FDA Prescribing Information

Antipsychotic Uses & Side Effects

Haldol (haloperidol) vs. Abilify (aripiprazole): What’s the distinction?

  • Haloperidol and Abilify (aripiprazole) are antipsychotic drugs used to deal with schizophrenia and Tourette’s syndrome.
  • Haloperidol can also be used to deal with acute psychosis.
  • Abilify can also be used to deal with bipolar dysfunction, irritability related to autistic dysfunction, and it’s used with different drugs to deal with main despair in adults.
  • A model title for haloperidol is Haldol.
  • Side results of haloperidol and Abilify which are comparable embrace nausea, weight acquire, insomnia, vomiting, and constipation.
  • Side results of haloperidol which are completely different from Abilify embrace extrapyramidal results (sudden, typically jerky, involuntary motions of the pinnacle, neck, arms, physique, or eyes; muscle stiffness, restlessness, Parkinsonism), dizziness, hyperactivity, tiredness, sedation, erectile dysfunction, menstrual irregularities, swelling of breast tissue in males (gynecomastia), dry mouth, and dizziness on standing throughout the first few weeks of remedy.
  • Side results of Abilify which are completely different from haloperidol embrace nervousness, blurred imaginative and prescient, cough, headache, lightheadedness, rash, restlessness, runny nostril, sleepiness, tremors, and weak spot.
  • Do not cease utilizing haloperidol or Abilify abruptly, or you might have disagreeable withdrawal signs.

What is Haloperidol? What is Abilify?

Haloperidol is an antipsychotic drug used to deal with schizophrenia, acute psychosis, and for remedy of tics and vocal utterances of Tourette’s syndrome. Haloperidol interferes with the results of neurotransmitters within the mind by blocking receptors for the neurotransmitters (particularly the dopamine and serotonin sort 2 receptors) on the nerves. As a end result, the nerves should not “activated” by the neurotransmitters launched by different nerves.

Abilify (aripiprazole) is an anti-psychotic drugs used to deal with schizophrenia, bipolar dysfunction, irritability related to autistic dysfunction, and Tourette’s dysfunction. It is also used with different drugs for the remedy of main despair in adults. The actual mechanism of motion of Abilify is unknown. Like different anti-psychotics, it blocks receptors on nerves within the mind for a number of neurotransmitters. It is believed that its useful impact is because of its results on dopamine and serotonin receptors. Its results on these receptors are advanced, involving stimulation of the receptors however to a lesser diploma than the naturally-occurring neurotransmitters (a course of known as partial agonism).



QUESTION


Schizophrenia is probably the most disabling psychological sickness.
See Answer

What are the unwanted side effects of haloperidol and Abilify?

Haloperidol

The most typical unwanted side effects related to Haldol are:

  • extrapyramidal results (sudden, typically jerky, involuntary motions of the pinnacle, neck, arms, physique, or eyes, muscle stiffness, akathisia, Parkinsonism),
  • dizziness,
  • hyperactivity,
  • tiredness, and
  • nausea.

Other necessary unwanted side effects are:

Haldol could trigger a situation known as “orthostatic hypotension” throughout the early section of remedy (first week or two). Orthostatic hypotension causes sufferers to change into dizzy upon arising from a mendacity or sitting place due to a drop in blood strain.

Haldol additionally could trigger irregular coronary heart beats, sudden demise, seizures, decreases in crimson and white blood cells, and withdrawal signs.

Elderly sufferers with dementia-related psychosis and handled with antipsychotic medication corresponding to Haldol are at an elevated danger of demise.

Abilify

WARNINGS

  • Long-term use of aripiprazole could result in a doubtlessly irreversible situation known as tardive dyskinesia (involuntary actions of the jaw, lips, and tongue).
  • A doubtlessly deadly advanced known as neuroleptic malignant syndrome has been reported with anti-psychotic medication, together with Abilify. Patients who develop this syndrome could have:
  • All atypical antipsychotic medication have been related to metabolic modifications corresponding to hyperglycemia, diabetes mellitus, dyslipidemia, and weight acquire. Serious circumstances of hyperglycemia resulting in coma or demise have been reported in sufferers handled with atypical antipsychotics. Although there is no such thing as a clear hyperlink between aripiprazole and diabetes, sufferers needs to be examined throughout remedy for elevated blood-sugars. Additionally, sufferers with danger elements for diabetes, together with weight problems or a household historical past of diabetes, ought to have their fasting ranges of blood sugar examined earlier than beginning remedy and periodically all through remedy to detect the onset of diabetes. Any affected person growing signs that counsel diabetes throughout medical remedy needs to be examined for diabetes.
  • Elderly sufferers with dementia-related psychosis handled with antipsychotics are at an elevated danger of demise and Abilify shouldn’t be used for this indication. Antidepressants elevated the danger of suicidal considering and conduct in short-term research in youngsters and adolescents with despair and different psychiatric problems. Anyone contemplating the usage of this drugs or every other antidepressant in a toddler or adolescent should steadiness this danger of suicide with the scientific want. Patients who’re began on medical remedy needs to be intently noticed for scientific worsening, suicidal ideas, or uncommon modifications in conduct.

Some of the most typical unwanted side effects embrace:

What is the dosage for haloperidol vs. Abilify?

Haloperidol

  • This dose for this medicine often is as soon as a day.
  • The typical grownup beginning oral dose for sufferers with schizophrenia or bipolar dysfunction is 10 to 15 mg as soon as each day. The dose could also be elevated over time as much as 30 mg each day to realize the specified impact.
  • The beneficial dose for sufferers with Tourette’s dysfunction is 5 to 20 mg as soon as each day.

Abilify

  • The beneficial oral dose for schizophrenia is 0.5-5 mg two or 3 times each day as much as a most dose of 30 mg each day. The lactate resolution dose is 2-5 mg each 4-Eight hours as wanted by intramuscular injection. The lactate resolution may additionally be administered by intravenous injection at 1-2 mg each 2-Four hours and titrated to impact. The most single injection dose is 50 mg and the utmost each day dose is 500 mg each day. The dose for the decanoate resolution is 10-20 occasions the each day oral dose as soon as month-to-month by intramuscular injection. The decanoate resolution shouldn’t be administered intravenously.
  • The beneficial dose for treating Tourette’s syndrome is 0.5-5 mg orally two or 3 times each day.



SLIDESHOW


Schizophrenia: Symptoms, Types, Causes, Treatment
See Slideshow

What medication work together with haloperidol and Abilify?

Haloperidol

Haldol causes sedation, and sedation could also be higher if Haldol is taken with alcohol and different medication that may trigger sedation such because the benzodiazepine class of anti-anxiety medication for instance:

The narcotic class of ache drugs and its derivatives for instance:

The tricyclic class of antidepressants for instance:

Some antihistamines for instance:

Certain antihypertensive drugs for instance:

Carbamazepine (Tegretol) could enhance the elimination of Haldol, rendering the Haldol much less efficient. Rifampin (Rifadin) could lower the elimination of Haldol, growing the danger of unwanted side effects from Haldol.

Abilify

  • Carbamazepine (Tegretol) can markedly lower the quantity of Abilify within the physique by growing the speed at which the physique’s enzymes (significantly the liver enzyme, CYP3A4) degrade it. The producer recommends that sufferers on this drug who’re began on carbamazepine double their dose of Abilify, underneath their physician’s supervision. Other medication that may promote the exercise of CYP3A4 and reduce the physique’s ranges of Abilify are phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital.
  • Ketoconazole (Nizoral) can enhance the quantity of aripiprazole within the physique by blocking CYP3A4. The producer of aripiprazole recommends decreasing the dose of aripiprazole by one-half throughout ketoconazole remedy. Many different medication are also recognized to dam CYP3A4 and doubtlessly may enhance the degrees of aripiprazole, however their precise results on aripiprazole ranges haven’t been studied. Such medication embrace:
  • Quinidine (Quinaglute, Quinidex) inhibits one other liver enzyme often known as CYP2D6 that additionally breaks down aripiprazole and may enhance the quantity of aripiprazole within the physique. The producer of aripiprazole recommends decreasing the dose of aripiprazole by one-half throughout quinidine remedy. Other medicines that block CYP2D6 embrace fluoxetine (Prozac) and paroxetine (Paxil).
  • Alpha-1 receptor blockers [doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin)], used for management of blood strain and prostatic enlargement, could enhance the prospect of hypotension (unusually low blood strain).

Are haloperidol and Abilify protected to make use of whereas pregnant or breastfeeding?

Haloperidol

  • Neonates uncovered to antipsychotics throughout the third trimester of being pregnant could develop withdrawal signs and extrapyramidal signs.
  • Haldol is secreted into breast milk. It shouldn’t be used whereas breast feeding.

Abilify

  • Aripiprazole has not been adequately studied throughout being pregnant. Neonates uncovered to antipsychotic medication within the third trimester could expertise withdrawal signs and different unwanted side effects. Your physician or different healthcare supplier could select to make use of this medicine if she or he feels that its advantages outweigh this potential concern.
  • It isn’t recognized if this drugs is excreted in breast milk; nonetheless, since most medicines are excreted in breast milk, docs and different well being care professionals suggest that girls shouldn’t breastfeed their toddler/child whereas taking Abilify.

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Medically Reviewed on 4/10/2020

References


FDA Prescribing Information

Abilify (aripiprazole) vs. Invega (paliperidone): Side Effects & Dosage

Abilify vs. Invega

  • Abilify (aripiprazole) and Invega (paliperidone) are antipsychotic medicine used to deal with schizophrenia.
  • A distinction is that Abilify can also be used to deal with mania, despair, bipolar problems, autistic problems, and a few irritable habits problems.
  • Common unwanted effects of Abilify and Invega embody:
  • Serious unwanted effects of Abilify and Invega embody:
  • Both Abilify and Invega could work together with different medicines that make you sleepy (equivalent to chilly or allergy medication, narcotic ache medication, sleeping capsules, muscle relaxers, and medication for seizures, despair, or anxiousness), drugs to deal with hypertension or a coronary heart situation, carbamazepine.
  • Abilify may additionally work together with:
  • Invega may additionally work together with:
    • arsenic trioxide,
    • droperidol,
    • anti-anxiety drugs,
    • antibiotics,
    • antidepressants,
    • anti-malaria drugs,
    • anti-seizure drugs,
    • medication to stop or deal with nausea and vomiting,
    • medicines to deal with Parkinson’s Disease,
    • medicines to deal with psychiatric problems, and
    • migraine headache medicines.

What is Abilify? What is Invega?

Abilify (aripiprazole) is a psychotropic drug (antipsychotic) that alters mind chemical exercise used to deal with schizophrenia, mania, despair, bipolar problems, autistic dysfunction, and a few irritable habits problems.

Invega (paliperidone) is an antipsychotic treatment used to deal with schizophrenia and schizoaffective dysfunction.

Abilify and Invega warnings, unwanted effects, and affected person security info

Abilify

WARNINGS

Long-term use of aripiprazole could result in a probably irreversible situation referred to as tardive dyskinesia (involuntary actions of the jaw, lips, and tongue).

A probably deadly advanced known as neuroleptic malignant syndrome has been reported with anti-psychotic medicine, together with Abilify. Patients who develop this syndrome could have:

All atypical antipsychotic medicine have been related to metabolic modifications equivalent to hyperglycemia, diabetes mellitus, dyslipidemia, and weight acquire. Serious circumstances of hyperglycemia resulting in coma or dying have been reported in sufferers handled with atypical antipsychotics. Although there isn’t a clear hyperlink between aripiprazole and diabetes, sufferers must be examined throughout therapy for elevated blood-sugars. Additionally, sufferers with danger elements for diabetes, together with weight problems or a household historical past of diabetes, ought to have their fasting ranges of blood sugar examined earlier than beginning therapy and periodically all through therapy to detect the onset of diabetes. Any affected person creating signs that recommend diabetes throughout medical therapy must be examined for diabetes.

Elderly sufferers with dementia-related psychosis handled with antipsychotics are at an elevated danger of dying and Abilify shouldn’t be used for this indication. Antidepressants elevated the danger of suicidal considering and habits in short-term research in kids and adolescents with despair and different psychiatric problems. Anyone contemplating the usage of this medication or another antidepressant in a toddler or adolescent should stability this danger of suicide with the scientific want. Patients who’re began on medical remedy must be carefully noticed for scientific worsening, suicidal ideas, or uncommon modifications in habits.

Some of the most typical unwanted effects embody:

Invega

The most typical unwanted effects embody

  • drowsiness,
  • weight acquire,
  • headache,
  • higher respiratory tract an infection,
  • elevated coronary heart fee,
  • constipation,
  • feeling restlessness or problem sitting nonetheless,
  • stiffness, and shuffling stroll,
  • tremors, and
  • gradual actions.

Less widespread however severe unwanted effects embody:

  • Increased danger of stroke and dying in aged sufferers with dementia-related psychosis.
  • Neuroleptic malignant syndrome (NMS): NMS is a uncommon however severe unwanted effects related to the usage of antipsychotics. NMS could lead to dying and should be handled within the hospital. Signs and signs of NMS could embody
  • excessive fever,
  • sweating (diaphoresis),
  • extreme muscle stiffness or rigidity,
  • confusion,
  • lack of consciousness,
  • hypertension,
  • speedy heartbeat, and
  • modifications in respiratory.
  • Extrapyramidal unwanted effects (EPS) together with:
    • Dystonia: painful spasms of the oral, throat, or neck muscular tissues that will trigger issues with speech, swallowing, and stiff neck.
    • Akathisia: emotions of restlessness or problem sitting nonetheless.
  • Pseudoparkinsonism: drug induced Parkinson’s signs.
  • Tardive dyskinesia (TD): Tardive dyskinesia normally happens after long-term use of antipsychotics and normally presents with motion issues affecting the tongue, lips, jaw, face, and extremities.
  • Metabolic modifications together with excessive blood sugar (hyperglycemia), diabetes mellitus, improve in blood ldl cholesterol, and weight acquire.
  • High blood ranges of prolactin. Prolactin is a hormone that enables the manufacturing of breast milk. High ranges of prolactin could trigger menstrual abnormalities, leakage of milk from the breast, growth of breast in males (gynecomastia), and erection issues in males.
  • Seizures

What are the medicine that work together with Abilify and Invega?

Abilify

  • Carbamazepine (Tegretol) can markedly lower the quantity of Abilify within the physique by growing the speed at which the physique’s enzymes (notably the liver enzyme, CYP3A4) degrade it. The producer recommends that sufferers on this drug who’re began on carbamazepine double their dose of Abilify, underneath their physician’s supervision. Other medicine that may promote the exercise of CYP3A4 and reduce the physique’s ranges of Abilify are phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital.
  • Ketoconazole (Nizoral) can improve the quantity of aripiprazole within the physique by blocking CYP3A4. The producer of aripiprazole recommends decreasing the dose of aripiprazole by one-half throughout ketoconazole remedy. Many different medicine are also recognized to dam CYP3A4 and probably might improve the degrees of aripiprazole, however their precise results on aripiprazole ranges haven’t been studied. Such medicine embody:
  • Quinidine (Quinaglute, Quinidex) inhibits one other liver enzyme generally known as CYP2D6 that additionally breaks down aripiprazole and might improve the quantity of aripiprazole within the physique. The producer of aripiprazole recommends decreasing the dose of aripiprazole by one-half throughout quinidine remedy. Other medicines that block CYP2D6 embody fluoxetine (Prozac) and paroxetine (Paxil).
  • Alpha-1 receptor blockers [doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin)], used for management of blood stress and prostatic enlargement, could improve the possibility of hypotension (unusually low blood stress).

Invega

Paliperidone could cause low blood stress particularly when standing up from a sitting or mendacity place (orthostatic hypotension). Therefore, paliperidone must be used cautiously with different medicine additionally related to orthostatic hypotension.

Paliperidone is metabolized (eradicated) by liver enzymes. Drugs that improve the motion of those enzymes will lower blood ranges of paliperidone thereby lowering its impact. Paliperidone shouldn’t be taken with carbamazepine (Tegretol), phenytoin (Dilantin), rifampin (Rifadin), St. John’s Wort, and different medicine that will lower its blood ranges.

Paliperidone blocks the impact of dopamine within the mind whereas dopamine agonists equivalent to levodopa (Sinemet) improve the degrees of dopamine within the mind. Combining these brokers is just not really useful because the impact of each medicine will likely be decreased.

Divalproex sodium will increase blood ranges of paliperidone by 50%. The dose of paliperidone must be adjusted based mostly on scientific judgment.

What is the dosage for Abilify vs. Invega?

Abilify

  • This dose for this treatment normally is as soon as a day.
  • The common grownup beginning oral dose for sufferers with schizophrenia or bipolar dysfunction is 10 to 15 mg as soon as each day. The dose could also be elevated over time as much as 30 mg each day to realize the specified impact.
  • The really useful dose for sufferers with Tourette’s dysfunction is 5 to 20 mg as soon as each day.

Invega

  • Paliperidone is run as soon as each day by mouth.
  • Tablets must be swallowed complete and shouldn’t be crushed, divided, or chewed.
  • The beginning dose for schizophrenia or schizoaffective dysfunction in adults is 6 mg each day.
  • The upkeep dose vary is three to 12 mg each day.
  • The most dose is 12 mg each day.
  • The dose for treating schizophrenia in adolescents weighing lower than 51 kg is three to six mg each day.
  • The dose for adolescents weighing greater than 51 kg is three to 12 mg each day.

Are Abilify and Invega Safe to Take During Pregnancy?

Abilify

Aripiprazole has not been adequately studied throughout being pregnant. Neonates uncovered to antipsychotic medicine within the third trimester could expertise withdrawal signs and different unwanted effects. Your physician or different healthcare supplier could select to make use of this treatment if she or he feels that its advantages outweigh this potential concern.

It is just not recognized if this medication is excreted in breast milk; nonetheless, since most medicines are excreted in breast milk, docs and different well being care professionals advocate that ladies shouldn’t breastfeed their toddler/child whereas taking this drug.

Invega

Unborn infants uncovered to antipsychotics through the third trimester of being pregnant are in danger for extrapyramidal and withdrawal signs after delivery. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed respiratory, and feeding dysfunction. Currently there isn’t a knowledge on the usage of paliperidone throughout being pregnant.

Paliperidone ought to solely be used throughout being pregnant if the potential profit to the mom outweighs the potential for unwanted effects within the fetus.
A being pregnant publicity registry has been established to observe the usage of atypical antipsychotics, together with paliperidone, throughout being pregnant.

All pregnant girls handled with atypical antipsychotics are suggested to enroll on this being pregnant registry and report any unwanted effects.

Paliperidone is understood to enter human milk however its results on the breastfeeding toddler or milk manufacturing is just not but recognized.

Medically Reviewed on 4/10/2020

References


FDA Prescribing Information

Cerdelga (eliglustat) Side Effects, Warnings, and Drug Interactions

What is Cerdelga (eliglustat) and the way is it used?

Cerdelga (eliglustat) is a prescription drugs used for the long-term therapy of Gaucher illness kind 1 (GD1) in adults.

Cerdelga shouldn’t be utilized in sure folks with Gaucher illness kind 1. Your physician will carry out a check to be sure that Cerdelga is best for you.

What are a very powerful negative effects and different information about Cerdelga (eliglustat)?

Cerdelga can have an effect on the best way different medicines work and different medicines can have an effect on how Cerdelga works. Using Cerdelga with different medicines or natural dietary supplements could trigger an elevated danger of negative effects.

Especially inform your physician if you happen to take:

  • St. John’s Wort (Hypericum perforatum)

Or drugs for:

If you are taking any medicines for the situations listed above, your physician could must prescribe a distinct drugs, change your dose of different medicines, or change your dose of Cerdelga. Tell your physician about any new medicines earlier than you begin taking them.

Avoid consuming or consuming grapefruit merchandise whereas taking Cerdelga. Grapefruit merchandise can enhance the quantity of Cerdelga in your physique.

Other negative effects of Cerdelga (eliglustat)

Cerdelga, used with sure different medicines, could trigger adjustments within the electrical exercise of your coronary heart (ECG adjustments) and irregular coronary heart beat (arrhythmias). Tell your physician when you have new signs corresponding to palpitations, fainting, or dizziness.

The commonest negative effects of Cerdelga embrace:

Tell your physician when you have any aspect impact that bothers you or that doesn’t go away.  These aren’t all of the potential negative effects of Cerdelga.

Call your physician for medical recommendation about negative effects. You could report negative effects to FDA at 1-800-FDA-1088.

What is the dosage for Cerdelga (eliglustat)?

  • Take Cerdelga precisely as your physician tells you to take it.
  • Your physician could change your dose if wanted.
  • Take Cerdelga capsules entire, ideally with water. Do not open, crush, or dissolve capsules earlier than swallowing.
  • Cerdelga might be taken with or with out meals.
  • If you miss a dose of Cerdelga, take the subsequent dose on the regular time. Do not take two doses of Cerdelga on the identical time.
  • If you are taking an excessive amount of Cerdelga, name your physician or go to the closest hospital emergency room immediately.

Cerdelga (eliglustat) contraindications, being pregnant security and drug interactions

It shouldn’t be identified if Cerdelga is protected and efficient in youngsters.

Before taking Cerdelga, inform your physician about your whole medical situations, together with if you happen to:

  • have coronary heart issues, together with a situation referred to as lengthy QT syndrome
  • have a historical past of a coronary heart assault
  • have kidney or liver issues
  • are pregnant or planning to grow to be pregnant. It shouldn’t be identified if Cerdelga will hurt your unborn child.
  • are breastfeeding or planning to breastfeed. It shouldn’t be identified if Cerdelga passes into your breast milk. You and your physician will determine if you happen to ought to take Cerdelga or breastfeed. You shouldn’t do each.

Tell your physician about the entire medicines you are taking, together with prescription and over-the-counter medicines, nutritional vitamins, and natural dietary supplements. 

 

Medically Reviewed on 4/17/2020

References


Article courtesy of the U.S. Food and Drug Administration

Dosage, Side Effects & Pregnancy Safety

What is Sublocade (buprenorphine) and the way is it used?

Sublocade is a prescription medication used to deal with adults with average to extreme dependancy (dependence) to opioid medicine (prescription or unlawful) who:

  • have obtained remedy with an oral transmucosal (used below the tongue or contained in the cheek) buprenorphine containing medication for 7 days and
  • are taking a dose that controls withdrawal signs for at the least seven days.
  • Sublocade is a part of a whole remedy plan that ought to embody counseling.

What are a very powerful uncomfortable side effects and different info about Sublocade (buprenorphine)?

WARNING

RISK OF SERIOUS HARM OR DEATH WITH INTRAVENOUS ADMINISTRATION; SUBLOCADE RISK EVALUATION AND MITIGATION STRATEGY

  • Serious hurt or dying may consequence if administered intravenously. Sublocade kinds a strong mass upon contact with physique fluids and will trigger occlusion, native tissue harm, and thrombo-embolic occasions, together with life threatening pulmonary emboli, if administered intravenously. 
  • Because of the danger of significant hurt or dying that might consequence from intravenous self administration, Sublocade is barely obtainable by way of a restricted program referred to as the Sublocade REMS Program. Healthcare settings and pharmacies that order and dispense Sublocade have to be licensed on this program and adjust to the REMS necessities. 
  • Because of the intense threat of potential hurt or dying from self-injecting Sublocade right into a vein (intravenously), it’s only obtainable by way of a restricted program referred to as the Sublocade REMS Program.
    • Sublocade is just not obtainable in retail pharmacies.
    • Your Sublocade injection will solely be given to you by a licensed healthcare supplier.
  • In an emergency, you or your loved ones ought to inform the emergency medical workers that you’re bodily depending on an opioid and are being handled with Sublocade.
  • Buprenorphine, the drugs in Sublocade, may cause severe and life-threatening issues, particularly should you take or use sure different medicines or medicine. Call your healthcare supplier immediately or get emergency assist should you:
    • really feel faint or dizzy
    • can’t assume effectively or clearly
    • have psychological adjustments equivalent to confusion
    • have a excessive physique temperature
    • have slower respiratory than you usually have
    • have slowed reflexes
    • have extreme sleepiness
    • really feel agitated
    • have blurred imaginative and prescient
    • have stiff muscle tissues
    • have issues with coordination
    • have bother strolling
    • have slurred speech

These might be indicators of an overdose or different severe issues.

What ought to I keep away from whereas being handled with Sublocade?

  • Do not drive, function heavy equipment, or carry out some other harmful actions till you know the way this medication impacts you. Buprenorphine may cause drowsiness and gradual response occasions. This might occur extra usually within the first few days after your injection and when your dose is modified.
  • Do not drink alcohol throughout remedy with Sublocade, as this will result in slowed respiratory, drowsiness, gradual response time, lack of consciousness and even dying.

Other uncomfortable side effects of Sublocade (buprenorphine)

Sublocade may cause severe uncomfortable side effects, together with:

  • Physical dependence and withdrawal. Your physique can develop a bodily want for Sublocade (dependence). If you cease receiving Sublocade, you might have opioid withdrawal signs equivalent to:

These signs might begin weeks to months after your final dose of Sublocade

  • Liver issues. Call your healthcare supplier immediately should you discover any of those indicators of liver issues:

Your healthcare supplier might do checks earlier than and through remedy with Sublocade to examine your liver.

  • Allergic response. Call your healthcare supplier or get emergency assist immediately should you get:
  • Decrease in blood stress. You might really feel dizzy whenever you rise up from sitting or mendacity down.

The most typical uncomfortable side effects of Sublocade embody:

Long-term (power) use of opioids, together with Sublocade, might trigger fertility issues in men and women. Talk to your healthcare supplier if this can be a concern for you.

These are usually not all of the potential uncomfortable side effects of Sublocade.

Call your physician for medical recommendation about uncomfortable side effects. You might report uncomfortable side effects to the FDA at 1-800-FDA-1088.

General details about Sublocade

Medicines are generally prescribed for functions aside from these listed in a Medication Guide. This Medication Guide summarizes necessary details about Sublocade. If you prefer to extra data discuss together with your healthcare supplier. You can ask your healthcare supplier for data that’s written for healthcare professionals.



SLIDESHOW


Addicted to Pills: The Health Risks of Drug Abuse
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What is the dosage for Sublocade (buprenorphine)?

  • You will obtain Sublocade by your healthcare supplier as an injection just below the pores and skin (subcutaneous) of your abdomen (stomach). You will obtain Sublocade month-to-month (with at the least 26 days between doses).
  • Sublocade is injected as a liquid. After the injection, Sublocade adjustments to a strong kind referred to as a depot. The depot could also be seen or felt as a small bump below your pores and skin on the injection web site in your stomach for a number of weeks. The depot will get smaller over time.
  • Do not attempt to take away the depot.
  • Do not rub or therapeutic massage the injection web site.
  • Try to not let belts or clothes waistbands rub in opposition to the injection web site.
  • If you miss a dose of Sublocade, see your healthcare supplier to get your Sublocade injection as quickly as potential.

Sublocade (buprenorphine) contraindications, being pregnant security and drug interactions

It is just not identified if Sublocade is protected or efficient in youngsters.

Sublocade is a managed substance (CIII) as a result of it comprises buprenorphine that may be a goal for individuals who abuse prescription medicines or road medicine.

Do not use Sublocade in case you are allergic to buprenorphine or any ingredient within the prefilled syringe (ATRIGEL® Delivery System). See the tip of this Medication Guide for an inventory of substances in Sublocade.

Sublocade will not be best for you. Before beginning Sublocade, inform your healthcare supplier about your entire medical situations, together with:

  • Trouble respiratory or lung issues
  • An enlarged prostate gland (males)
  • A head damage or mind downside
  • Problems urinating
  • A curve in your backbone that impacts your respiratory (scoliosis)
  • Liver issues
  • Gallbladder issues
  • Adrenal gland issues
  • Addison’s illness
  • Low thyroid hormone ranges (hypothyroidism)
  • A historical past of alcoholism
  • Mental issues equivalent to hallucinations (seeing or listening to issues that aren’t there).
  • Are pregnant or plan to turn into pregnant. If you obtain Sublocade whereas pregnant, your child might have signs of opioid withdrawal at start.
  • Are breastfeeding or plan to breastfeed. Sublocade can go into your breast milk and will hurt your child. Talk together with your healthcare supplier about the easiest way to feed your child throughout remedy with Sublocade. Watch your child for elevated drowsiness and respiratory issues.

Tell your healthcare supplier about all of the medicines you are taking, together with prescription and over-the-counter medicines, nutritional vitamins and natural dietary supplements. Sublocade might have an effect on the way in which different medicines work and different medicines might have an effect on how Sublocade works. Some medicines might trigger severe or life-threatening medical issues when taken with Sublocade.

  • The doses of sure medicines might should be modified if used throughout remedy with Sublocade. Do not take any medication throughout remedy with Sublocade till you could have talked together with your healthcare supplier. Your healthcare supplier will let you know whether it is protected to take different medicines throughout remedy with Sublocade.
  • You shouldn’t take anxiousness medicines or benzodiazepines (equivalent to Valium® or Xanax®), sleeping tablets, tranquilizers, muscle relaxants, or sedatives (equivalent to Ambien®), antidepressants, or antihistamines that aren’t prescribed to you throughout remedy with Sublocade, as this will result in slowed respiratory, drowsiness, delayed response time, lack of consciousness and even dying. If a healthcare supplier is contemplating prescribing such a drugs for you, remind the healthcare supplier that you’re being handled with Sublocade.
  • You might have detectable ranges of Sublocade in your physique for a protracted interval after stopping remedy with Sublocade.

Know the medicines you are taking. Keep an inventory of them to point out your healthcare supplier and pharmacist every time you get a brand new medication.

Medically Reviewed on 4/21/2020

References


Article courtesy of the U.S. Food and Drug Administration

Dosage, Side Effects & Pregnancy Safety

What is Promacta (eltrombopag) and the way is it used?

Promacta is a prescription drugs used to deal with adults and youngsters 1 yr of age and older with low blood platelet counts resulting from persistent immune thrombocytopenia (ITP), when different medicines to deal with ITP or surgical procedure to take away the spleen haven’t labored nicely sufficient.

Promacta can also be used to deal with folks with:

  • low blood platelet counts resulting from persistent hepatitis C virus (HCV) an infection earlier than and through therapy with interferon.
  • extreme aplastic anemia (SAA) together with different medicines to deal with SAA, as the primary therapy for adults and youngsters 2 years of age and older.
  • extreme aplastic anemia (SAA) when different medicines to deal with SAA haven’t labored nicely sufficient.

Promacta is used to attempt to increase platelet counts with a purpose to decrease your threat for bleeding.

Promacta will not be used to make platelet counts regular.

What are an important unwanted side effects and different information about Promacta (eltrombopag)?

WARNING

RISK FOR HEPATIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEPATITIS C

RISK OF HEPATOTOXICITY

In sufferers with persistent hepatitis C, Promacta together with interferon and ribavirin might improve the danger of hepatic decompensation.

Promacta might improve the danger of extreme and probably life-threatening hepatotoxicity. Monitor hepatic operate and discontinue dosing as advisable

Promacta may cause critical unwanted side effects, together with:

Liver issues:

  • If you’ve persistent hepatitis C virus and take Promacta with interferon and ribavirin therapy, Promacta might improve your threat of liver issues. If your healthcare supplier tells you to cease your therapy with interferon and ribavirin, additionally, you will must cease taking Promacta.
  • Promacta might improve your threat of liver issues which may be extreme and presumably life threatening. Your healthcare supplier will do blood checks to examine your liver operate earlier than you begin taking Promacta and through your therapy. Your healthcare supplier might cease your therapy with Promacta when you have modifications in your liver operate blood checks.

Tell your healthcare supplier instantly when you have any of those indicators and signs of liver issues:

  • yellowing of the pores and skin or the whites of the eyes (jaundice)
  • uncommon darkening of the urine
  • uncommon tiredness
  • proper higher abdomen space (stomach) ache
  • confusion
  • swelling of the abdomen space (stomach)

Other unwanted side effects of Promacta (eltrombopag)

Promacta might trigger critical unwanted side effects, together with:

  • Increased threat of worsening of a precancerous blood situation referred to as myelodysplastic syndrome (MDS) to acute myelogenous leukemia (AML). Promacta will not be to be used in folks with a precancerous situation referred to as myelodysplastic syndromes (MDS). If you’ve MDS and obtain Promacta, you’ve an elevated threat that your MDS situation might worsen and grow to be a blood most cancers referred to as AML. If your MDS worsens to grow to be AML, you’ll have an elevated threat of demise from AML.
  • High platelet counts and better threat for blood clots. Your threat of getting a blood clot is elevated in case your platelet depend is simply too excessive throughout therapy with Promacta. Your threat of getting a blood clot might also be elevated throughout therapy with Promacta when you have regular or low platelet counts.
    • You might have extreme issues or die from some types of blood clots, equivalent to clots that journey to the lungs or that trigger coronary heart assaults or strokes. Your healthcare supplier will examine your blood platelet counts, and alter your dose or cease Promacta in case your platelet counts get too excessive.
    • Tell your healthcare supplier instantly when you have indicators and signs of a blood clot within the leg, equivalent to swelling, ache, or tenderness in your leg. People with persistent liver illness could also be in danger for a kind of blood clot within the abdomen space (stomach).
    • Tell your healthcare supplier instantly when you have stomach-area (stomach) ache, nausea, vomiting, or diarrhea as these could also be signs of this sort of blood clot.
  • New or worsened cataracts (a clouding of the lens within the eye). New or worsened cataracts can occur in folks taking Promacta. Your healthcare supplier will examine your eyes earlier than and through your therapy with Promacta. Tell your healthcare supplier about any modifications in your eyesight whereas taking Promacta.

The commonest unwanted side effects of Promacta in adults and youngsters embody:

Laboratory checks might present irregular modifications to the cells in your bone marrow.

Tell your healthcare supplier when you have any aspect impact that bothers you or that doesn’t go away. These aren’t all the attainable unwanted side effects of Promacta. For extra data, ask your healthcare supplier or pharmacist.

Call your physician for medical recommendation about unwanted side effects. You might report unwanted side effects to FDA at 1-800-FDA-1088.



SLIDESHOW


Anemia Symptoms and Signs, Types, Treatment and Causes
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What is the dosage for Promacta (eltrombopag)?

  • Take Promacta precisely as your healthcare supplier tells you to take it. Your healthcare supplier will prescribe the dose of Promacta tablets or Promacta for oral suspension that’s best for you.
  • If your healthcare supplier prescribes Promacta tablets, take Promacta tablets complete. Do not cut up, chew, or crush Promacta tablets and don’t combine with meals or liquids.
  • If your healthcare supplier prescribes Promacta for oral suspension, see the “Instructions for Use” that comes along with your drugs for directions on easy methods to appropriately combine and take a dose of Promacta.
  • Use a brand new single-use oral dosing syringe to organize every dose of Promacta for oral suspension. Do not re-use the oral dosing syringe.
  • Do not cease taking Promacta with out speaking along with your healthcare supplier first. Do not change your dose or schedule for taking Promacta until your healthcare supplier tells you to vary it.
  • Take Promacta on an empty abdomen, both 1 hour earlier than or 2 hours after consuming meals.
  • Take Promacta at the very least 2 hours earlier than or Four hours after consuming dairy merchandise and calcium-fortified juices.
  • If you miss a dose of Promacta, wait and take your subsequent scheduled dose. Do not take greater than 1 dose of Promacta in 1 day.
  • If you are taking an excessive amount of Promacta, you’ll have the next threat of significant unwanted side effects. Call your healthcare supplier instantly.
  • Your healthcare supplier will examine your platelet depend throughout your therapy with Promacta and alter your dose of Promacta as wanted.
  • Tell your healthcare supplier about any bruising or bleeding that occurs whilst you take and after you cease taking Promacta.
  • If you’ve SAA, your healthcare supplier might do checks to watch your bone marrow throughout therapy with Promacta.

What ought to I keep away from whereas taking Promacta?

Avoid conditions and medicines that will improve your threat of bleeding.

Promacta (eltrombopag) contraindications, being pregnant security and drug interactions

Promacta will not be to be used in folks with a pre-cancerous situation referred to as myelodysplastic syndrome (MDS), or in folks with low platelet counts brought on by sure different medical circumstances or ailments.

It will not be identified if Promacta is secure and efficient when used with different antiviral medicines to deal with persistent hepatitis C.

It will not be identified if Promacta is secure and efficient in kids:

  • youthful than 1 yr with ITP
  • with low blood platelet counts resulting from persistent hepatitis C
  • whose extreme aplastic anemia (SAA) has not improved after earlier therapies.
  • youthful than 2 years when utilized in mixture with different medicines to deal with SAA as the primary therapy for SAA.

Before you are taking Promacta, inform your healthcare supplier about all your medical circumstances, together with in case you:

  • have liver issues
  • have a precancerous situation referred to as MDS or a blood most cancers
  • have or had a blood clot
  • have a historical past of cataracts
  • have had surgical procedure to take away your spleen (splenectomy)
  • have bleeding issues
  • are of Asian ancestry (equivalent to Chinese, Japanese, Taiwanese, or Korean). You may have a decrease dose of Promacta.
  • are pregnant or plan to grow to be pregnant. It will not be identified if Promacta will hurt an unborn child. Tell your healthcare supplier in case you grow to be pregnant or suppose it’s possible you’ll be pregnant throughout therapy with Promacta.
    • Females who’re in a position to grow to be pregnant, ought to use efficient contraception (contraception) throughout therapy with Promacta and for at the very least 7 days after stopping therapy with Promacta. Talk to your healthcare supplier about contraception strategies which may be best for you throughout this time.
  • are breastfeeding or plan to breastfeed. You shouldn’t breastfeed throughout your therapy with Promacta. Talk to your healthcare supplier about one of the best ways to feed your child throughout this time.

Tell your healthcare supplier about all of the medicines you are taking, together with prescription and over-the-counter medicines, nutritional vitamins, and natural dietary supplements. Promacta might have an effect on the way in which sure medicines work. Certain different medicines might have an effect on the way in which Promacta works.

Especially inform your healthcare supplier in case you take:

Certain medicines might hold Promacta from working appropriately. Take Promacta at the very least 2 hours earlier than or Four hours after taking these merchandise:

  • antacid drugs used to deal with abdomen ulcers or heartburn
  • multivitamins or merchandise that comprise iron, calcium, aluminum, magnesium, selenium, and zinc which can be present in mineral dietary supplements

Ask your healthcare supplier in case you are unsure in case your drugs is one that’s listed above.

Know the medicines you are taking. Keep a listing of them and present it to your healthcare supplier and pharmacist whenever you get a brand new drugs.




QUESTION


Sickle cell illness is called after a farming instrument.
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Medically Reviewed on 4/22/2020

References


Article courtesy of the U.S. Food and Drug Administration